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StarSpirit
Updated:28/07/2024
Biological treatments are a key advancement in psoriasis management, targeting specific components of the immune system.
What is Psoriasis?
Psoriasis is a chronic autoimmune condition characterized by accelerated skin cell production, resulting in red, scaly patches on the skin.
How do Biological Treatments Work?
- Targeting the Immune System: Biological treatments focus on specific parts of the immune system responsible for the inflammation and overproduction of skin cells.
- Types of Biological Treatments:
- TNF-alpha inhibitors (e.g., Etanercept, Infliximab)
- IL-12/23 inhibitors (e.g., Ustekinumab)
- IL-17A inhibitors (e.g., Secukinumab)
- IL-23 inhibitors (e.g., Guselkumab)
Mechanism of Action
| Type of Biological | Mechanism |
|---|---|
| TNF-alpha inhibitors | Block a protein involved in systemic inflammation |
| IL-12/23 inhibitors | Reduce inflammatory responses by inhibiting cytokines |
| IL-17A inhibitors | Block the action of IL-17A, a key player in inflammation |
| IL-23 inhibitors | Target IL-23 to decrease T-cell activation and proliferation |
Benefits of Biological Treatments
- Long-lasting effects
- Targeted action, reducing systemic side effects
- Improvement in quality of life due to effective symptom control
Side Effects and Considerations
- Increased risk of infections
- Injection site reactions
- Potential long-term effects on the immune system
Statistical Overview of Treatment Efficacy
| Biological Treatment | Response Rate (≥75% Improvement) |
|---|---|
| Etanercept | 50% |
| Infliximab | 70-80% |
| Ustekinumab | 60-70% |
| Secukinumab | 70-90% |
| Guselkumab | 80% |
Mind Map of Biological Treatment Effectiveness
- Biological Treatments
- Immune System Targeting
- Specific Cytokines
- T-Cell Functions
- Types
- TNF-alpha Inhibitors
- IL-12/23 Inhibitors
- IL-17A Inhibitors
- IL-23 Inhibitors
- Benefits
- Improvement in Quality of Life
- Long-Lasting Effects
- Considerations
- Infection Risk
- Injection Reactions
- Immune System Targeting
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