Plaque psoriasis is a chronic autoimmune condition that causes raised, red patches covered with silvery scales. In 2023, several advancements in treatments have emerged.

1. Biologics

Biologics are among the most effective treatments for moderate to severe plaque psoriasis. They target specific parts of the immune system that drive inflammation.

• Examples include:
  • Ilumya (tildrakizumab)
  • Skyrizi (risankizumab)
  • Dupixent (dupilumab)
• Mechanism of Action:
  • Inhibit interleukin (IL)-23 or IL-17 pathways.
• Administration:
  • Subcutaneous injection every few weeks or monthly.

2. Systemic Treatments

Oral systemic treatments are also in use:

• Apremilast (Otezla):
  • Mechanism: Inhibits phosphodiesterase 4 (PDE4) to reduce inflammation.
  • Administration: Taken as a daily pill.
• Methotrexate:
  • Mechanism: Immunosuppressant that slows cell growth.
  • Administration: Weekly oral dosing.

3. Topical Treatments

Topicals are still an important part of treatment for mild to moderate cases:

• Corticosteroids:
  • Quick relief of inflammation.
• Vitamin D analogs:
  • Calcipotriene reduces scaling and lesions.
• Tazarotene (topical retinoid):
  • Reduces inflammation and skin cell turnover.

4. Phototherapy

Phototherapy remains a viable treatment, especially for those preferring non-systemic options:

• Types of phototherapy include:
  • UVB therapy
  • PUVA (psoralen + UVA)
• Benefits:
  • Improves symptoms without medication side effects.

5. Emerging Treatments

Several new treatments are in development:

• New biologics (e.g. bimekizumab)
• New systemic agents targeting different cytokines.

Statistics

Mind Map of Treatments

1. Treatments for Plaque Psoriasis

• Biologics
• Systemic Treatments
• Topical Treatments
• Phototherapy
• Emerging Treatments

Conclusion

In 2023, plaque psoriasis treatments are advancing with new biologics, systemic options, and improved topical therapies. It is essential to consult a healthcare provider for personalized treatment plans.